Trypanosoma Brucei breaking through the Endothelial Cell Layer

Educational Animation for the Wellcome Center for Integrative Parasitology

Snippet of the animation created to explain the infection mechanism employed by the trypanaosome parasite. Specifically the crossing of the blood brain barrier (BBB). Trypanosoma brucei causes African Sleeping Sickness (AFS) and is one of the major tropical diseases in sub-Saharan africa. WHO Neglected Tropical Diseases Roadmap targetet AFS for 2020 elimination as a public health problem.

Trypanosoma brucei movement study

The layers the parasite has to cross aided by T-Cells before reaching the brain Parenchyma and sucesfully completing the crossing of the BBB.